PUBLICATIONS
2023
Blair LM, Juan JM, Sebastian L, Tran VB, Nie W, Wall GD, Gerceker M, Lai IK, Apilado EA, Grenot G, Amar D, Foggetti G, Do Carmo M, Ugur Z, Deng D, Chenchik A, Paz Zafra M, Dow LE, Politi K, MacQuitty JJ, Petrov DA, Winslow MM, Rosen MJ, Winters IP. Oncogenic context shapes the fitness landscape of tumor suppression. Nat Commun. 2023 Oct 12;14(1):6422 [PMID: 37828026] [LINK] [PDF]
Katti A, Vega-Pérez A, Foronda M, Zimmerman J, Zafra MP, Granowsky E, Goswami S, Gardner EE, Diaz BJ, Simon JM, Wuest A, Luan W, Fernandez MTC, Kadina AP, Walker JA 2nd, Holden K, Lowe SW, Sánchez Rivera FJ, Dow LE. Generation of precision preclinical cancer models using regulated in vivo base editing. Nature Biotechnology 2023 Aug 10 [PMID: 37563300] [LINK] [PDF]
Sánchez Rivera FJ, Dow LE. How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research. Cold Spring Harb Perspect Med. 2023 Jul 24:a041384. [PMID: 37487630] [LINK] [PDF]
van der Mijn JC, Laursen KB, Fu L, Khani F, Dow LE, Nowak DG, Chen Q, Gross SS, Nanus DM, Gudas LJ. Novel genetically engineered mouse models for clear cell renal cell carcinoma. Sci Rep. 2023 May 22;13(1):8246. [PMID: 37217526] [LINK] [PDF]
Bhardwaj P, Iyengar NM, Zahid H, Carter KM, Byun DJ, Choi MH, Sun Q, Savenkov O, Louka C, Liu C, Piloco P, Acosta M, Bareja R, Elemento O, Foronda M, Dow LE, Oshchepkova S, Giri DD, Pollak M, Zhou XK, Hopkins BD, Laughney AM, Frey MK, Ellenson LH, Morrow M, Spector JA, Cantley LC, Brown KA. Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. Sci Transl Med. 2023 Feb 22;15(684):eade1857. [PMID: 36812344] [LINK] [PDF]
2022
Villanueva JW, Kwong L, Han T, Martinez SA, Shanahan MT, Kanke M, Dow LE, Danko CG, Sethupathy P. Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival. BMC Genomics. 2022 Dec 1;23(1):792. [PMID: 36457077] [LINK] [PDF]
Amen AM, Loughran RM, Huang CH, Lew RJ, Ravi A, Guan Y, Schatoff EM, Dow LE, Emerling BM, Fellmann C. Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. Cell Rep Methods. 2022 Jun 21;2(7):100239. [PMID: 35880017] [LINK] [PDF]
Tang F, Xu D, Wang S, Wong CK, Martinez-Fundichely A, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, de Stanchina E, Berger MF, Gopalan A, Dow LE, Mosquera JM, Beltran H, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y, Khurana E. Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science. 2022 May 27;376(6596):eabe1505. [PMID: 35617398] [LINK] [PDF]
Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O'Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW. A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17) [PMID: 35442775] [LINK] [PDF]
Katti A, Diaz BJ, Caragine CM, Sanjana NE, Dow LE. CRISPR in cancer biology and therapy. Nature Reviews Cancer. 2022 May;22(5):259-279 [PMID: 35194172] [LINK] [PDF]
Sánchez-Rivera FJ, Diaz BJ, Kastenhuber ER, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravarty D, Zhang H, Leslie CS, Lowe SW, Dow LE Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nature Biotechnology. 2022 Feb 14. doi: 10.1038/s41587-021-01172-3 [PMID: 35165384] [LINK] [PDF]
Doan A, Arand J, Gong D, Drainas AP, Shue YT, Lee MC, Zhang S, Walter DM, Chaikovsky AC, Feldser DM, Vogel H, Dow LE, Skotheim JM, Sage J RB depletion is required for the continuous growth of tumors initiated by loss of RB. PLoS Genetics. 2021 Dec 8;17(12):e1009941 [PMID: 34879057] [LINK] [PDF]
2021
Alonso S, Dow LE. Engineering chromosome rearrangements in cancer. Dis Model Mech. 2021 Sep 1;14(9):dmm049078 [PMID: 34585724] [LINK] [PDF]
Parsons MJ, Tammela T, Dow LE. WNT as a Driver and Dependency in Cancer. Cancer Discovery. 2021 Oct;11(10):2413-2429 [PMID: 34518209] [LINK] [PDF]
Taylor SR, Ramsamooj S, Liang RJ, Katti A, Pozovskiy R, Vasan N, Hwang SK, Nahiyaan N, Francoeur NJ, Schatoff EM, Johnson JL, Shah MA, Dannenberg AJ, Sebra RP, Dow LE, Cantley LC, Rhee KY, Goncalves MD. Dietary fructose improves intestinal cell survival and nutrient absorption. Nature. 2021 Sep;597(7875):263-267. [PMID: 34408323] [LINK] [PDF]
Zafra MP, Dow LE. Revealing ARID1A Function in Gastric Cancer from the Bottom Up. Cancer Discovery. 2021 Jun;11(6):1327-1329 [PMID: 34078662] [LINK] [PDF]
Krumm CS, Xu X, Bare CJ, Holman CD, Kersten S, Dow LE, Lee AH, Cohen DE. Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice J Biol Chem. 2021 Jul;297(1):100815 [PMID: 34023388] [LINK] [PDF]
Kim JK, Marco MR, Choi SH, Qu X, Chen CT, Elkabets M, Fairchild L, Chow O, Barriga FM, Dow LE, O'Rourke K, Szeglin B, Yarilin D, Fujisawa S, Manova-Todorova K, Paty PB, Shia J, Leslie C, Joshua Smith J, Lowe S, Pelossof R, Sanchez-Vega F, Garcia-Aguilar J. KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix. Mol Oncol. 2021 Oct;15(10):2766-2781 [PMID: 33817986] [LINK] [PDF]
Montrose DC, Saha S, Foronda M, McNally EM, Chen J, Zhou XK, Ha T, Krumsiek J, Buyukozkan M, Verma A, Elemento O, Yantiss RK, Chen Q, Gross SS, Galluzzi L, Dow LE, Dannenberg AJ. Exogenous and endogenous sources of serine contribute to colon cancer metabolism, growth, and resistance to 5-fluorouracil. Cancer Research. 2021 Feb 1:canres.1541.2020. [PMID: 33526512] [LINK] [PDF]
Ouchi T, Morimura S, Dow LE, Miyoshi H, Udey MC EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase. Cells. 2021 Jan 28;10(2):256. [PMID: 33525555] [LINK] [PDF]
2020
Zafra MP, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Calvo Fernandez MT, Wilkinson JE, Piskounova E, Dow LE An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants Cancer Discovery 2020 10.1158/2159-8290.CD-20-0442 [PMID: 32792368] [LINK] [PDF]
Han T, Goswami S, Hu Y, Tang F, Zafra MP, Murphy C, Cao Z, Poirier JT, Khurana E, Elemento O, Hechtman JF, Ganesh K, Yaeger R, Dow LE. Lineage Reversion Drives WNT Independence in Intestinal Cancer. Cancer Discovery. 2020 Oct;10(10):1590-1609. doi: 10.1158/2159-8290.CD-19-1536. [PMID: 32546576] [LINK] [PDF]
Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. Journal of Experimental Medicine. 2020 Oct 5;217(10):e20200140. doi: 10.1084/jem.20200140. [PMID: 32648916] [LINK] [PDF]
Morral C, Stanisavljevic J, Hernando-Momblona X, Mereu E, Álvarez-Varela A, Cortina C, Stork D, Slebe F, Turon G, Whissell G, Sevillano M, Merlos-Suárez A, Casanova-Martí À, Moutinho C, Lowe SW, Dow LE, Villanueva A, Sancho E, Heyn H, Batlle E Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer. Cell Stem Cell. 2020 Jun 4;26(6):845-861.e12. doi: 10.1016/j.stem.2020.04.012. [PMID: 32396863] [LINK] [PDF]
Hinze L, Labrosse R, Degar J, Han T, Schatoff EM, Schreek S, Karim S, McGuckin C, Sacher JR, Wagner F, Stanulla M, Yuan C, Sicinska E, Giannakis M, Ng K, Dow LE, Gutierrez A. Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discovery. 2020 Jul 23. doi: 10.1158/2159-8290.CD-19-1472. [PMID: 32703769] [LINK] [PDF]
Katti A, Dow LE. Base editing goes into hyperdrive. Nature Cell Biology. 2020 Jun;22(6):617-618. [PMID: 32393885] [LINK] [PDF]
Leibold J, Ruscetti M, Cao Z, Ho YJ, Baslan T, Zou M, Abida W, Feucht J, Han T, Barriga FM, Tsanov KM, Zamechek L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado NR, Sánchez-Rivera FJ, Watson PA, de Stanchina E, Wilkinson JE, Dow LE, Abate-Shen C, Sawyers CL, Lowe SW Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis. Cancer Discovery. 2020 Jul;10(7):1038-1057. doi: 10.1158/2159-8290.CD-19-1242. [PMID: 32376773] [LINK] [PDF]
Billon P, Nambiar TS, Hayward SB, Zafra MP, Schatoff EM, Oshima K, Dunbar A, Breinig M, Park YC, Ryu HS, Tschaharganeh DF, Levine RL, Baer R, Ferrando A, Dow LE, Ciccia A Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures. Cell Reports 2020 Mar 10;30(10):3280-3295 [PMID: 32160537] [LINK] [PDF]
Katti A, Foronda M, Zimmerman J, Diaz B, Zafra MP, Goswami S, Dow LE GO: a functional reporter system to identify and enrich base editing activity. Nucleic Acids Res. 2020 Apr 6;48(6):2841-2852. doi: 10.1093/nar/gkaa124. [PMID: 32112097] [LINK] [PDF]
Annunziato S, Lutz C, Henneman L, Bhin J, Wong K, Siteur B, van Gerwen B, de Korte-Grimmerink R, Zafra MP, Schatoff EM, Drenth AP, van der Burg E, Eijkman T, Mukherjee S, Boroviak K, Wessels LF, van de Ven M, Huijbers IJ, Adams DJ, Dow LE, Jonkers J . In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer. EMBO journal, 2020 Jan 13:e102169 [PMID: 31930530] [LINK] [PDF]
Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G Anderson, David R. Liu, Hao Yin, Wen Xue . Adenine base editing in an adult mouse model of tyrosinaemia. Nature Biomedical Engineering. 2020 Jan;4(1):125-130 [PMID: 31740768] [LINK] [PDF]
2019
Foronda M, Tarumoto Y, Schatoff EM, Leach BI, Diaz BJ, Zimmerman J, Goswami S, Shusterman M, Vakoc CR, Dow LE (2019). Tankyrase inhibition sensitizes cells to CDK4 blockade. PLoS One. 2019 Dec 31;14(12):e0226645 [PMID: 31891587] [LINK] [PDF]
Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC. (2019) Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature Medicine, Nov;25(11):1739-1747 [PMID: 31700183] [LINK] [PDF]
Ganesh K, Wu C, …. Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ (2019). A rectal cancer organoid platform to study individual responses to chemoradiation. Nature Medicine, October 7th, https://doi.org/10.1038/s41591-019-0584-2 [PMID:31591597] [LINK] [PDF]
Romesser PB, Kim AS, Jeong J, Mayle A, Dow LE, Lowe SW. (2019) Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome. PNAS Sep 24. pii: 201906611. [PMID: 31551264] [LINK] [PDF]
Schatoff EM, Goswami S, Zafra MP, Foronda M, Shusterman M, Leach BI, Katti A, Diaz BJ, Dow LE (2019) Distinct CRC-associated APC mutations dictate response to Tankyrase inhibition. Cancer Discovery. 2019 Jul 23. pii: CD-19-0289. doi: 10.1158/2159-8290.CD-19-0289 [PMID: 31337618] [LINK] [PDF]
Schatoff EM, Paz Zafra M, Dow LE. (2019) Base Editing the Mammalian Genome. Methods. Mar 2. pii: S1046-2023(18)30318-9. doi: 10.1016/j.ymeth.2019.02.022. [PMID: 30836137] [LINK] [PDF]
Mishra A, Emamgholi F, Erlangga Z, Hartleben B, Unger K, Wolff K, Teichmann U, Kessel M, Woller N, Kühnel F, Dow LE, Manns MP, Vogel A, Lowe SW, Saborowski A, Saborowski M (2019) Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing. Carcinogenesis. Jun 6 [PMID: 31170286] [LINK] [PDF]
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW (2019) Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. Jun 4;130 [PMID: 31162141] [LINK] [PDF]
Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC (2019) PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell Reports. Cell Rep. 2019 May 14;27(7):1991-2001.e5 [PMID: 31091439] [LINK] [PDF]
Saborowski A, Wolff K, Spielberg S, Beer B, Hartleben B, Erlangga Z, Becker D, Dow LE, Marhenke S, Woller N, Unger K, Schirmacher P, Manns MP, Marquardt JU, Vogel A, Saborowski M. (2019). Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro. Hepatology Communications. Feb 5;3(3):423-436. [PMID: 30859153] [LINK] [PDF]
Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. (2019). Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Reports. Jan 2;26(1):192-208.e6. doi: 10.1016/j.celrep.2018.12.036. [PMID: 30605676] [LINK] [PDF]
2018
Foronda M & Dow LE (2018). CRISPR: Stressed about p53?. Trends Mol Med. 2018 Sep;24(9):731-733 [PMID: 3001753] [LINK] [PDF]
Maria Paz Zafra#, Emma M Schatoff#, Alyna Katti, Miguel Foronda, Marco Breinig, Anabel Y. Schweitzer, Amber Simon, Teng Han, Sukanya Goswami, Emma Montgomery, Jordana Thibado, Edward R Kastenhuber, Francisco J. Sánchez-Rivera, Junwei Shi, Christopher R Vakoc, Scott W Lowe, Darjus F. Tschaharganeh, Lukas E Dow (2018). Optimized base editors enable efficient editing in cells, organoids and mice. Nature Biotechnology, Oct;36(9):888-893 [PMID: 29969439] [LINK] [PDF]
Ventura A & Dow LE (2018). Modeling cancer in the CRISPR era. Annual Reviews in Cancer Biology. Vol. 2:111-131 [PDF]
2017
Han, T, Schatoff, EM, Murphy, C, Zafra, MP, Wilkinson, JE, Elemento, O, Dow, LE (2017). R-Spondin chromosome rearrangements drive Wnt-dependent tumor initiation and maintenance in the intestine. Nature Communications. Jul 11;8:15945. doi: 10.1038/ncomms15945 [PMID: 28695896] [LINK] [PDF]
O'Rourke KP, Loizou E, Livshits G, Schatoff EM, Baslan T, Manchado E, Simon J, Romesser PB, Leach B, Han T, Pauli C, Beltran H, Rubin MA, Dow LE#, Lowe SW# (2017). Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nature Biotechnology. May 1st doi: 10.1038/nbt.3837 # corresponding authors [PMID: 28459450] [LINK] [PDF]
Schatoff ES, Leach BI, Dow LE (2017). WNT Signaling and Colorectal Cancer. Curr Colorectal Cancer Rep 13: 101. doi:10.1007/s11888-017-0354-9
2016
Zafra MP and Dow LE (2016). Somatic Genome Editing Goes Viral. Trends Mol Med. Aug 20. pii: S1471-4914(16)30100-9. [ PMID: 27555346]
O'Rourke KP, Dow LE, Lowe SW (2016) Immunofluorescent Staining of Mouse Intestinal Stem Cells. Bio Protoc. Feb 20;6(4). pii: e1732 [PMID: 27570798]
O'Rourke KP, Ackerman S, Dow LE, Lowe SW (2016). Isolation, Culture and Maintenance of Mouse Intestinal Stem Cells. Bio Protoc. Feb 20;6(4). pii: e1733 [PMID: 27570799]
Lindemans CA, Mertelsmann AM, O’Connor MH, Calafiore M, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu Y, Hua G, Martin ML, O’Rourke KP, Lo Y, Mokry M, Romera-Hernandez M, Cupedo T, Dow LE, Nieuwenhuis EE2, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, and Hanash AM. (2016) Interleukin-22 Is an Intestinal Stem Cell Growth Factor Linking Immunity to Epithelial Regeneration. Nature, Dec 24;528(7583):560-4 [PMID: 26649819]
2015
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015 Nov 5. pii: aaa5004. [PMID: 26541605]
Dow LE. (2015) Modeling Disease In Vivo With CRISPR/Cas9. Trends in Molecular Medicine. Oct; 21(10):609-21 [PMID: 26432018]
Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryn LM, Axelsson E, Schweifer N, Tontsch-Grunt U, Dow LE, Gianni D, Pearson M, Valent P, Stark A, Kraut N, Vakoc CR, Zuber J. (2015) Transcriptional Plasticity Promotes Primary and Acquired Resistance to BET Inhibition. Nature. Sept 24;525(7570):543-547 [PMID: 26367798]
Dow LE*, O’Rourke KP*, Simon J, Tschaharganeh DF, Van Es JH, Clevers H, Lowe SW. (2015) Apc restoration promotes cellular differentiation and re-establishes crypt homeostasis in colorectal cancer. Cell. June 18;161(7):1539-1552 [PMID: 26091037] * equal contribution
Dow LE*#, Fisher J*, O’Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci N, Lowe SW#. (2015) Inducible in vivo genome editing with CRISPR/Cas9. Nature Biotechnology. [PMID: 25690852] * equal contribution, #corresponding author
2014
Bolden JE*, Tasdemir N*, Dow LE*, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW. (2014) Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition. Cell Reports. 2014 Sep 17. pii: S2211-1247(14)00688-3. * equal contribution [PMID: 25242322]
Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. (2014) p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell. 2014 Jul 31;158(3):579-92. [PMID: 25083869]
Dow LE, Nasr Z, Saborowski S, Ebbesen SH, Manchado E, Tasdemir N, Lee T, Pelletier J, Lowe SW (2014) Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice. PLoS One April 17, DOI: 10.1371/journal.pone.0095236 [PMID: 24743474]
Saborowski M, Saborowski A, Morris JP IV, Bosbach B, Dow LE, Pelletier J, Klimstra DS, Lowe SW. (2014) A modular and flexible ESC-based mouse model of pancreatic cancer. Genes & Development. Jan 1;28(1):85-97 [PMID: 24395249]
2013
Premsrirut PK, Dow LE, Park Y, Hannon GJ, Lowe SW (2013). Creating Transgenic shRNA Mice by Recombinase-Mediated Cassette Exchange. Cold Spring Harb Protoc. Sep 1;2013(9) [PMID: 24003198]
Takiguchi M, Dow LE, Prier JE, Carmichael CL, Kile BT, Turner SJ, Lowe SW, Huang DC, Dickins RA (2013). Variability of Inducible Expression across the Hematopoetic System of Tetracycline Transactivator Transgenic Mice. PLoS One. 8(1):e54009. [PMID: 23326559]
2012
Dow LE and Lowe SW (2012). Life in the fast lane: Mammalian disease models in the genomic era. Cell. Mar 16;148(6):1099-109 [PMID: 22424222]
Dow LE*, Premsrirut PK*, Zuber J*, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW (2012) A pipeline for the generation of shRNA transgenic mice. Nature Protocols, Feb 2;7(2):374-93 * equal contribution [PMID: 22301776]
2011
Pearson HB, Perez-Mancera, PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R and Humbert PO (2011). SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia, J. Clin Invest, Nov 1;121(11):4257-67 [PMID: 21695329]
McJunkin K, Mazurek A, Premsrirut PK, Zuber J, Dow LE, Simon J, Stillman B and Lowe SW (2011) Reversible suppression of an essential gene in adult mice using transgenic RNA interference. PNAS; Apr 26;108(17):7113-8. [PMID: 21482754]
Premsrirut PK*, Dow LE*, Miething C, Camiolo M, Kim SY, Malone CD, Scuoppo C, Zuber J, Dickins RA, Kogan S, Sordella R, Hannon GJ and Lowe SW (2011) A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell. Vol. 145 (1) pp. 145-58 *equal contribution [PMID: 21458673]
Zuber J, McJunkin K, Fellmann C, Dow LE, Taylor M, Hannon GJ, Lowe SW (2011). A toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotech Vol. 29(1) pp.79-83 [PMID: 21131983]
Pre-2010
Dow LE, Elsum IA, King CL, Kinross KM, Richardson HE, Humbert PO. (2008). Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signaling. Oncogene. Oct 9;27(46):5988-6001 [PMID: 18641685]
Dow LE and Humbert PO. (2007) Polarity regulators and the control of epithelial architecture, cell migration and tumourigenesis Int Rev Cytol.262:253-302 [PMID: 17631191]
Humbert PO, Dow LE, Russell, SM. (2006) The Scribble and Par complexes in the regulation of polarity and migration: Friends or Foes? Trends in Cell Biology, Dec;16(12):622-30 [PMID: 17067797]
Dow LE, Kauffman JS, Caddy J, Peterson A, Jane SM, Russell SM, Humbert PO. (2007) The tumour suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene, Apr 5;26(16):2272-82 [PMID: 17043654]
Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, Ellis S, Smyth MJ, Kershaw MH, Darcy PK, Humbert PO and Russell SM (2005) A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity. 22:737-48 [PMID: 15963788]
Dow LE, Brumby AM, Muratore R, Coombe ML, Sedelies KA, Trapani JA, Russell SM, Richardson HE and Humbert PO. (2003). hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 22: 9225-30 [PMID: 14681682]